Two things I think are cool are video games and children (they are, you know, our future). So I whole-heartedly endorse Child's Play, the charity started by the guys from Penny Arcade, which gets donations of toys, games, books and cash to sick kids in children's hospitals around the world. You can make a straight donation, you can buy toys or games directly from Amazon and have them shipped straight to a hospital, you participate in an event, or you can even buy a PS3.