If you only go to one comedy show this weekend, it should probably be one of the Laughing Matters: Katrina Relief shows.
If you go to two shows, well then you should hit up the special Saturday midnight Don't Spit the Water show, which is a fund-raiser for their planned trip to New York to do a show at the UCB Theater. Rumor has it that a certain Ms. Cutie Bumblesnatch will be performing.
If you see three shows, my goodness that's a lot, and I'd be pleased as punch if the third show were the Neutrino Project tonight. We've only got four shows left. I think I'm going to wear a tux tonight. How could that not entice you?